Founding developers Tony Kim, Yanping Zhang and Mark Schnitzer
The curved Crystal Skull replaces the dorsal cranium of a mouse. It was developed by a group led by Tony Kim and Yanping Zhang in Mark Schnitzer's lab at Stanford. It gives optical access to an estimated 800,000–1,100,000 individual neurons across neocortex in GCaMP expressing mice. Using Ca2+ imaging 25,000–50,000 neocortical mouse neurons were accessible across multiple focal planes.
LabMaker Crystal Skull glasses are made from Schott-Glass for superior optical quality. They are laser-cut, and curved by annealing on a custom-mold in a temperature-controlled kiln.
(1) R10: 8 x 9 mm, curved with a 10 mm radius
(2) R12: 8 x 10 mm, curved with a 12mm radius
Kim TH, Zhang Y, Lecoq J, Jung JC, Li J, Zeng H, Niell CM & Schnitzer MJ (2016). Long-Term Optical Access to an Estimated One Million Neurons in the Live Mouse Cortex. Cell Reports, 17:3385–3394