Founding developer Mathew Rynes, Leila Ghanbari, Micheal Laroque, Greg Johnson, Daniel Sousa Schulman and Suhasa Kodandaramaiah

Add-ons for Craniobot
  • Replacement z-axis probe - $139.00 USD (details)
  • Stereotaxic ear and bite bars - Pack of 5 - $395.00 USD (details)

Founding developer Mathew Rynes, Leila Ghanbari, Micheal Laroque, Greg Johnson, Daniel Sousa Schulman and Suhasa Kodandaramaiah

The Craniobot microsurgical platform was developed by Suhasa Kodandaramaiah and Mathew Rynes and the team at the Bio-Sensing and Bio-Robotics Laboratory at the University of Minnesota - Twin Cities.

The Craniobot is a cranial microsurgery platform that combines automated skull surface profiling with a computer numerical controlled (CNC) milling machine to perform a variety of cranial microsurgical procedures in mice. The Craniobot utilizes a low force contact sensor to profile the skull surface and uses this information to perform micrometer-scale precise milling operations within minutes. The procedure of removing the sub-millimeter thick mouse skull precisely without damaging the underlying brain can be technically challenging and often takes significant skill and practice. This can now be overcome using the Craniobot.


      • CNC controller board with a 32 bit ARM microprocessor
      • Swiss-engineered Maxon 24V spindle motor
      • Spindle motor speed controller for manual adjustment
      • Z-axis probe with a low force contact sensor
      • 0.3mm end-mill bit and 0.3mm ball head (with 4mm shaft)
      • Collets for 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5 and 7 mm shafts
      • Thorlabs breadboard (M6 holes) with posts and clamps
      • Stereotaxic ear bar (x2), Stereotaxic bite bar (x1)


        • Machine dimensions: 420mm x 355mm x 310 mm (LxWxH)
        • Stereotaxic platform dimensions: 200 mm x 200 mm
        • Maximum milling area: 145 mm x 200 mm x 55 mm (x-, y-, z-axis)
        • Weight: 7 Kg


        The Craniobot Courier is a custom Graphical User’s Interface that runs in a MATLAB environment. This software allows the user to probe complex topographies and generate tool-paths tailored to each surface. The z-axis probe measures and stores point by point and generates a point-cloud. This point-cloud is then used to calculate the milling tool-path based on the surface mapped.


            • Stereotaxic ear and bite mount bars - Pack of 5
            • Replacment z-axis probe

                The z-axis probe is prone to damage but can easily be replaced.

                For any further enquiries related to this product, please contact us.


                Leila Ghanbari, Mathew L. Rynes, Jia Hu, Daniel S. Schulman, Gregory W. Johnson, Michael Laroque, Gabriella M. Shull & Suhasa B. Kodandaramaiah (2019). Craniobot: A computer numerical controlled robot for cranial microsurgeries. Scientific Reports.

                Rynes ML, Ghanbari L, Schulman DS, Linn S, Laroque M, Dominguez J, Navabi ZS, Sherman P & Kodandaramaiah SB (2020). Assembly and operation of an open-source, computer numerical controlled (CNC) robot for performing cranial microsurgical procedures. Nature Protocols.

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